Insulin and leptin oscillations license food-entrained browning and metabolic flexibility
Summary: Timed feeding drives adipose browning, although the integrative mechanisms for ACNEDOTE FACE SCRUB the same remain unclear.Here, we show that twice-a-night (TAN) feeding generates biphasic oscillations of circulating insulin and leptin, representing their entrainment by timed feeding.Insulin and leptin surges lead to marked cellular, funct